Chloroquine and hemoglobin

Sep 11, 2018 · By examining gene-edited parasites, we report that the ability of the wide-spread Dd2 PfCRT isoform to mediate chloroquine and amodiaquine resistance is substantially reduced by the addition of the PfCRT L272F mutation, which arose under blasticidin selection. Compounds that Aug 21, 2020 · The most accepted, but simplified hypothesis, is that the CQ accumulation inside of the food vacuole (FV) interferes with the detoxification of heme, the product of hemoglobin catabolism ( 3, 11 )

2024-03-29
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  1. falciparum chloroquine resistance transporter (pfcrt)
  2. INTRODUCTION
  3. falciparum chloroquine resistance transporter (pfcrt)